Prednisone as a Rheumatic Disorders Remedy
Prednisone belongs to the class of corticosteroids of a wide spectrum. Its mechanism of action is based on suppression of polymorphonuclear leukocytes, glucose transport and phosphorylation. Prednisone can reduce inflammation and relieve pain; due to these qualities it is often used to treat rheumatic disorders, including rheumatism, rheumatoid arthritis, osteoarthrosis, injuries of joints and backbone nerves. It’s necessary to mention that Prednisone may be used both for maintenance therapy and for short-term therapy, depending on each patient’s individual case. Also, in spite of some recommendations, the dosage must be defined by a doctor according to the tests, disease history and personal sensitivity to the drug.
Corticosteroids, including Prednisone, are often prescribed to patients with rheumatism because they are able to make clinical symptoms disappear in a short period of time and normalize immunological processes. Patients feel better nearly at once, the temperature lowers and pathological changes in joints pass away. However, it’s better to combine Prednisone with salycylates or pyrazolone derivatives to increase an anti-inflammatory effect and decrease the risk of withdrawals and exacerbation.
When doctors prescribe Prednisone to patients with rheumatism, they usually point out 250-300 mg as a total amount of the medicine for one therapy regimen. Patients are to take 5 mg pill of Prednisone 3-6 times a say. In severe cases dosage may be increased. Also, it’s crucial for Prednisone not to be cancelled abruptly – gradual decreasing of dosage is necessary to avoid withdrawal states.
Rheumatoid Arthritis and Prednisone
It’s claimed that high doses of Prednisone are to be used only in patients with severe rheumatic arthritis cases because of its possible side effects and toxic reactions. However, low doses (less than 10 mg per day) are quite effective at an early period of rheumatic arthritis disease when first symptoms appear. Prednisone helps to decrease pain in the joints and improve functional activity, slow down radiographic progression of arthral destruction, and to enhance basic therapy effectiveness.
If patients with rheumatic arthritis experience bad inflammation, polyarticular damage and basic anti-inflammatory medicines are not enough effective, Prednisone is prescribed for about 6-month period in low doses up to 10 mg per day. High doses of Prednisone for short periods of time are prescribed in severe cases of rheumatic arthritis.
Osteoarthrosis is not accompanied by such sharp pain and inflammation as in case with arthritis, so it’s not recommended to take Prednisone in ordinary cases of this disease. One more reason to avoid Prednisone is it has a bad influence on arthrosis cartilage metabolism. However, it may be prescribed for short periods of time in a combination with other medicines for rapid treatment of inflammation.
Injuries of Joints and Backbone Nerves
This type of injuries is usually accompanied by severe pain and inflammatory process. Of course, necessity of Prednisone prescription is defined by a doctor in each individual case to avoid unfavorable side effects. Ordinary dosage, if there are more advantages than disadvantages in taking corticosteroids, is 5-10 mg 3-4 times a day.